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cgas genbank  (ATCC)


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    Structured Review

    ATCC cgas genbank
    Cgas Genbank, supplied by ATCC, used in various techniques. Bioz Stars score: 90/100, based on 4 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/cgas+genbank/pUC-Cathepsin+G/pm30566866-254-153-185
    Average 90 stars, based on 4 article reviews
    cgas genbank - by Bioz Stars, 2026-10
    90/100 stars

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    Related Articles

    Enzyme-linked Immunosorbent Assay:

    Article Title: The Cyclopeptide Astin C Specifically Inhibits the Innate Immune CDN Sensor STING.
    Article Snippet: REAGENT or RESOURCE SOURCE IDENTIFIER Critical Commercial Assays Mouse IFN-b ELISA kit PBL assay science Cat#42400-1 Fluoro HepANA Test kit MBL Cat#4220-12CN FastStart Universal SYBR Green Master(ROX) Roche Cat#34226600 Monolith NT.115 Series Capillaries Nanotemper Cat#MO-K005 Monolith Protein labeling kit RED-NHS Nanotemper Cat#MO-L001 CellTiter 96 AQueous One Solution Cell Proliferation Assay (MTS) Promega Cat#G3580 BCA Protein Assay Kit Thermo Scientific Cat#23227 Deposited Data The gene and gene product information of STING GenBank (http://www.ncbi.nlm.nih.gov/Genbank) NM_198282.3, NP_938023.1 The gene and gene product information of SCAP GenBank (http://www.ncbi.nlm.nih.gov/Genbank) NM_012235.2, NP_036367.2 The gene and gene product information of TBK1 GenBank (http://www.ncbi.nlm.nih.gov/Genbank) NM_013254.3, NP_037386.1 The gene and gene product information of IRF3 GenBank (http://www.ncbi.nlm.nih.gov/Genbank) NM_001197122.1, NP_001184051.1 The gene and gene product information of AMFR GenBank (http://www.ncbi.nlm.nih.gov/Genbank) NM_001144.5, NP_001135.3 The gene and gene product information of MAVS GenBank (http://www.ncbi.nlm.nih.gov/Genbank) NM_020746.4, NP_065797.2 The gene and gene product information of INSIG1 GenBank (http://www.ncbi.nlm.nih.gov/Genbank) NM_005542.4, NP_005533.2 The gene and gene product information of cGAS GenBank (http://www.ncbi.nlm.nih.gov/Genbank) NM_138441.2, NP_612450.2 The gene and gene product information of p65 GenBank (http://www.ncbi.nlm.nih.gov/Genbank) NM_021975.3, NP_068810.3 Protein structure of STING C-terminal domain PDB (http://www.rcsb.org/pdb/home/home.do) 4F5D Experimental Models: Cell Lines Mouse: MEFs ATCC Cat#SCRC-1008 Mouse: STING knockout MEFs (Chen et al., 2011) N/A Mouse: Raw264.7 ATCC Cat#TIB-71 Human: HEK293 ATCC Cat# CRL-1573 Human: HEK293T ATCC Cat#ACS-4500 Human: PBMC Allcells Cat#PB003F Human: IMR-90 Cobioer Bioscience Cat#CBP60912 Experimental Models: Organisms/Strains C57BL/6J The Jackson Laboratory Cat#000664 Trex1+/ mice (Hasan et al., 2015) N/A Oligonucleotides See Table S2 for ISD This paper N/A See Table S2 for HSV 60-mer This paper N/A Poly(dA:dT) Sigma Cat#P0883 Poly(I:C) Sigma Cat#P1530 See Table S2 for qPCR primer sequences This paper N/A Recombinant DNA Gene mutants and truncations, see plasmids part in Methods details This paper N/A Software and Algorithms GraphPad Prism 7 GraphPad Software https://www.graphpad.com/ scientific-software/prism/ Origin 8 Origin Lab https://www.originlab.com

    SYBR Green Assay:

    Article Title: The Cyclopeptide Astin C Specifically Inhibits the Innate Immune CDN Sensor STING.
    Article Snippet: REAGENT or RESOURCE SOURCE IDENTIFIER Critical Commercial Assays Mouse IFN-b ELISA kit PBL assay science Cat#42400-1 Fluoro HepANA Test kit MBL Cat#4220-12CN FastStart Universal SYBR Green Master(ROX) Roche Cat#34226600 Monolith NT.115 Series Capillaries Nanotemper Cat#MO-K005 Monolith Protein labeling kit RED-NHS Nanotemper Cat#MO-L001 CellTiter 96 AQueous One Solution Cell Proliferation Assay (MTS) Promega Cat#G3580 BCA Protein Assay Kit Thermo Scientific Cat#23227 Deposited Data The gene and gene product information of STING GenBank (http://www.ncbi.nlm.nih.gov/Genbank) NM_198282.3, NP_938023.1 The gene and gene product information of SCAP GenBank (http://www.ncbi.nlm.nih.gov/Genbank) NM_012235.2, NP_036367.2 The gene and gene product information of TBK1 GenBank (http://www.ncbi.nlm.nih.gov/Genbank) NM_013254.3, NP_037386.1 The gene and gene product information of IRF3 GenBank (http://www.ncbi.nlm.nih.gov/Genbank) NM_001197122.1, NP_001184051.1 The gene and gene product information of AMFR GenBank (http://www.ncbi.nlm.nih.gov/Genbank) NM_001144.5, NP_001135.3 The gene and gene product information of MAVS GenBank (http://www.ncbi.nlm.nih.gov/Genbank) NM_020746.4, NP_065797.2 The gene and gene product information of INSIG1 GenBank (http://www.ncbi.nlm.nih.gov/Genbank) NM_005542.4, NP_005533.2 The gene and gene product information of cGAS GenBank (http://www.ncbi.nlm.nih.gov/Genbank) NM_138441.2, NP_612450.2 The gene and gene product information of p65 GenBank (http://www.ncbi.nlm.nih.gov/Genbank) NM_021975.3, NP_068810.3 Protein structure of STING C-terminal domain PDB (http://www.rcsb.org/pdb/home/home.do) 4F5D Experimental Models: Cell Lines Mouse: MEFs ATCC Cat#SCRC-1008 Mouse: STING knockout MEFs (Chen et al., 2011) N/A Mouse: Raw264.7 ATCC Cat#TIB-71 Human: HEK293 ATCC Cat# CRL-1573 Human: HEK293T ATCC Cat#ACS-4500 Human: PBMC Allcells Cat#PB003F Human: IMR-90 Cobioer Bioscience Cat#CBP60912 Experimental Models: Organisms/Strains C57BL/6J The Jackson Laboratory Cat#000664 Trex1+/ mice (Hasan et al., 2015) N/A Oligonucleotides See Table S2 for ISD This paper N/A See Table S2 for HSV 60-mer This paper N/A Poly(dA:dT) Sigma Cat#P0883 Poly(I:C) Sigma Cat#P1530 See Table S2 for qPCR primer sequences This paper N/A Recombinant DNA Gene mutants and truncations, see plasmids part in Methods details This paper N/A Software and Algorithms GraphPad Prism 7 GraphPad Software https://www.graphpad.com/ scientific-software/prism/ Origin 8 Origin Lab https://www.originlab.com

    Labeling:

    Article Title: The Cyclopeptide Astin C Specifically Inhibits the Innate Immune CDN Sensor STING.
    Article Snippet: REAGENT or RESOURCE SOURCE IDENTIFIER Critical Commercial Assays Mouse IFN-b ELISA kit PBL assay science Cat#42400-1 Fluoro HepANA Test kit MBL Cat#4220-12CN FastStart Universal SYBR Green Master(ROX) Roche Cat#34226600 Monolith NT.115 Series Capillaries Nanotemper Cat#MO-K005 Monolith Protein labeling kit RED-NHS Nanotemper Cat#MO-L001 CellTiter 96 AQueous One Solution Cell Proliferation Assay (MTS) Promega Cat#G3580 BCA Protein Assay Kit Thermo Scientific Cat#23227 Deposited Data The gene and gene product information of STING GenBank (http://www.ncbi.nlm.nih.gov/Genbank) NM_198282.3, NP_938023.1 The gene and gene product information of SCAP GenBank (http://www.ncbi.nlm.nih.gov/Genbank) NM_012235.2, NP_036367.2 The gene and gene product information of TBK1 GenBank (http://www.ncbi.nlm.nih.gov/Genbank) NM_013254.3, NP_037386.1 The gene and gene product information of IRF3 GenBank (http://www.ncbi.nlm.nih.gov/Genbank) NM_001197122.1, NP_001184051.1 The gene and gene product information of AMFR GenBank (http://www.ncbi.nlm.nih.gov/Genbank) NM_001144.5, NP_001135.3 The gene and gene product information of MAVS GenBank (http://www.ncbi.nlm.nih.gov/Genbank) NM_020746.4, NP_065797.2 The gene and gene product information of INSIG1 GenBank (http://www.ncbi.nlm.nih.gov/Genbank) NM_005542.4, NP_005533.2 The gene and gene product information of cGAS GenBank (http://www.ncbi.nlm.nih.gov/Genbank) NM_138441.2, NP_612450.2 The gene and gene product information of p65 GenBank (http://www.ncbi.nlm.nih.gov/Genbank) NM_021975.3, NP_068810.3 Protein structure of STING C-terminal domain PDB (http://www.rcsb.org/pdb/home/home.do) 4F5D Experimental Models: Cell Lines Mouse: MEFs ATCC Cat#SCRC-1008 Mouse: STING knockout MEFs (Chen et al., 2011) N/A Mouse: Raw264.7 ATCC Cat#TIB-71 Human: HEK293 ATCC Cat# CRL-1573 Human: HEK293T ATCC Cat#ACS-4500 Human: PBMC Allcells Cat#PB003F Human: IMR-90 Cobioer Bioscience Cat#CBP60912 Experimental Models: Organisms/Strains C57BL/6J The Jackson Laboratory Cat#000664 Trex1+/ mice (Hasan et al., 2015) N/A Oligonucleotides See Table S2 for ISD This paper N/A See Table S2 for HSV 60-mer This paper N/A Poly(dA:dT) Sigma Cat#P0883 Poly(I:C) Sigma Cat#P1530 See Table S2 for qPCR primer sequences This paper N/A Recombinant DNA Gene mutants and truncations, see plasmids part in Methods details This paper N/A Software and Algorithms GraphPad Prism 7 GraphPad Software https://www.graphpad.com/ scientific-software/prism/ Origin 8 Origin Lab https://www.originlab.com

    Proliferation Assay:

    Article Title: The Cyclopeptide Astin C Specifically Inhibits the Innate Immune CDN Sensor STING.
    Article Snippet: REAGENT or RESOURCE SOURCE IDENTIFIER Critical Commercial Assays Mouse IFN-b ELISA kit PBL assay science Cat#42400-1 Fluoro HepANA Test kit MBL Cat#4220-12CN FastStart Universal SYBR Green Master(ROX) Roche Cat#34226600 Monolith NT.115 Series Capillaries Nanotemper Cat#MO-K005 Monolith Protein labeling kit RED-NHS Nanotemper Cat#MO-L001 CellTiter 96 AQueous One Solution Cell Proliferation Assay (MTS) Promega Cat#G3580 BCA Protein Assay Kit Thermo Scientific Cat#23227 Deposited Data The gene and gene product information of STING GenBank (http://www.ncbi.nlm.nih.gov/Genbank) NM_198282.3, NP_938023.1 The gene and gene product information of SCAP GenBank (http://www.ncbi.nlm.nih.gov/Genbank) NM_012235.2, NP_036367.2 The gene and gene product information of TBK1 GenBank (http://www.ncbi.nlm.nih.gov/Genbank) NM_013254.3, NP_037386.1 The gene and gene product information of IRF3 GenBank (http://www.ncbi.nlm.nih.gov/Genbank) NM_001197122.1, NP_001184051.1 The gene and gene product information of AMFR GenBank (http://www.ncbi.nlm.nih.gov/Genbank) NM_001144.5, NP_001135.3 The gene and gene product information of MAVS GenBank (http://www.ncbi.nlm.nih.gov/Genbank) NM_020746.4, NP_065797.2 The gene and gene product information of INSIG1 GenBank (http://www.ncbi.nlm.nih.gov/Genbank) NM_005542.4, NP_005533.2 The gene and gene product information of cGAS GenBank (http://www.ncbi.nlm.nih.gov/Genbank) NM_138441.2, NP_612450.2 The gene and gene product information of p65 GenBank (http://www.ncbi.nlm.nih.gov/Genbank) NM_021975.3, NP_068810.3 Protein structure of STING C-terminal domain PDB (http://www.rcsb.org/pdb/home/home.do) 4F5D Experimental Models: Cell Lines Mouse: MEFs ATCC Cat#SCRC-1008 Mouse: STING knockout MEFs (Chen et al., 2011) N/A Mouse: Raw264.7 ATCC Cat#TIB-71 Human: HEK293 ATCC Cat# CRL-1573 Human: HEK293T ATCC Cat#ACS-4500 Human: PBMC Allcells Cat#PB003F Human: IMR-90 Cobioer Bioscience Cat#CBP60912 Experimental Models: Organisms/Strains C57BL/6J The Jackson Laboratory Cat#000664 Trex1+/ mice (Hasan et al., 2015) N/A Oligonucleotides See Table S2 for ISD This paper N/A See Table S2 for HSV 60-mer This paper N/A Poly(dA:dT) Sigma Cat#P0883 Poly(I:C) Sigma Cat#P1530 See Table S2 for qPCR primer sequences This paper N/A Recombinant DNA Gene mutants and truncations, see plasmids part in Methods details This paper N/A Software and Algorithms GraphPad Prism 7 GraphPad Software https://www.graphpad.com/ scientific-software/prism/ Origin 8 Origin Lab https://www.originlab.com

    Bicinchoninic Acid Protein Assay:

    Article Title: The Cyclopeptide Astin C Specifically Inhibits the Innate Immune CDN Sensor STING.
    Article Snippet: REAGENT or RESOURCE SOURCE IDENTIFIER Critical Commercial Assays Mouse IFN-b ELISA kit PBL assay science Cat#42400-1 Fluoro HepANA Test kit MBL Cat#4220-12CN FastStart Universal SYBR Green Master(ROX) Roche Cat#34226600 Monolith NT.115 Series Capillaries Nanotemper Cat#MO-K005 Monolith Protein labeling kit RED-NHS Nanotemper Cat#MO-L001 CellTiter 96 AQueous One Solution Cell Proliferation Assay (MTS) Promega Cat#G3580 BCA Protein Assay Kit Thermo Scientific Cat#23227 Deposited Data The gene and gene product information of STING GenBank (http://www.ncbi.nlm.nih.gov/Genbank) NM_198282.3, NP_938023.1 The gene and gene product information of SCAP GenBank (http://www.ncbi.nlm.nih.gov/Genbank) NM_012235.2, NP_036367.2 The gene and gene product information of TBK1 GenBank (http://www.ncbi.nlm.nih.gov/Genbank) NM_013254.3, NP_037386.1 The gene and gene product information of IRF3 GenBank (http://www.ncbi.nlm.nih.gov/Genbank) NM_001197122.1, NP_001184051.1 The gene and gene product information of AMFR GenBank (http://www.ncbi.nlm.nih.gov/Genbank) NM_001144.5, NP_001135.3 The gene and gene product information of MAVS GenBank (http://www.ncbi.nlm.nih.gov/Genbank) NM_020746.4, NP_065797.2 The gene and gene product information of INSIG1 GenBank (http://www.ncbi.nlm.nih.gov/Genbank) NM_005542.4, NP_005533.2 The gene and gene product information of cGAS GenBank (http://www.ncbi.nlm.nih.gov/Genbank) NM_138441.2, NP_612450.2 The gene and gene product information of p65 GenBank (http://www.ncbi.nlm.nih.gov/Genbank) NM_021975.3, NP_068810.3 Protein structure of STING C-terminal domain PDB (http://www.rcsb.org/pdb/home/home.do) 4F5D Experimental Models: Cell Lines Mouse: MEFs ATCC Cat#SCRC-1008 Mouse: STING knockout MEFs (Chen et al., 2011) N/A Mouse: Raw264.7 ATCC Cat#TIB-71 Human: HEK293 ATCC Cat# CRL-1573 Human: HEK293T ATCC Cat#ACS-4500 Human: PBMC Allcells Cat#PB003F Human: IMR-90 Cobioer Bioscience Cat#CBP60912 Experimental Models: Organisms/Strains C57BL/6J The Jackson Laboratory Cat#000664 Trex1+/ mice (Hasan et al., 2015) N/A Oligonucleotides See Table S2 for ISD This paper N/A See Table S2 for HSV 60-mer This paper N/A Poly(dA:dT) Sigma Cat#P0883 Poly(I:C) Sigma Cat#P1530 See Table S2 for qPCR primer sequences This paper N/A Recombinant DNA Gene mutants and truncations, see plasmids part in Methods details This paper N/A Software and Algorithms GraphPad Prism 7 GraphPad Software https://www.graphpad.com/ scientific-software/prism/ Origin 8 Origin Lab https://www.originlab.com

    Knock-Out:

    Article Title: The Cyclopeptide Astin C Specifically Inhibits the Innate Immune CDN Sensor STING.
    Article Snippet: REAGENT or RESOURCE SOURCE IDENTIFIER Critical Commercial Assays Mouse IFN-b ELISA kit PBL assay science Cat#42400-1 Fluoro HepANA Test kit MBL Cat#4220-12CN FastStart Universal SYBR Green Master(ROX) Roche Cat#34226600 Monolith NT.115 Series Capillaries Nanotemper Cat#MO-K005 Monolith Protein labeling kit RED-NHS Nanotemper Cat#MO-L001 CellTiter 96 AQueous One Solution Cell Proliferation Assay (MTS) Promega Cat#G3580 BCA Protein Assay Kit Thermo Scientific Cat#23227 Deposited Data The gene and gene product information of STING GenBank (http://www.ncbi.nlm.nih.gov/Genbank) NM_198282.3, NP_938023.1 The gene and gene product information of SCAP GenBank (http://www.ncbi.nlm.nih.gov/Genbank) NM_012235.2, NP_036367.2 The gene and gene product information of TBK1 GenBank (http://www.ncbi.nlm.nih.gov/Genbank) NM_013254.3, NP_037386.1 The gene and gene product information of IRF3 GenBank (http://www.ncbi.nlm.nih.gov/Genbank) NM_001197122.1, NP_001184051.1 The gene and gene product information of AMFR GenBank (http://www.ncbi.nlm.nih.gov/Genbank) NM_001144.5, NP_001135.3 The gene and gene product information of MAVS GenBank (http://www.ncbi.nlm.nih.gov/Genbank) NM_020746.4, NP_065797.2 The gene and gene product information of INSIG1 GenBank (http://www.ncbi.nlm.nih.gov/Genbank) NM_005542.4, NP_005533.2 The gene and gene product information of cGAS GenBank (http://www.ncbi.nlm.nih.gov/Genbank) NM_138441.2, NP_612450.2 The gene and gene product information of p65 GenBank (http://www.ncbi.nlm.nih.gov/Genbank) NM_021975.3, NP_068810.3 Protein structure of STING C-terminal domain PDB (http://www.rcsb.org/pdb/home/home.do) 4F5D Experimental Models: Cell Lines Mouse: MEFs ATCC Cat#SCRC-1008 Mouse: STING knockout MEFs (Chen et al., 2011) N/A Mouse: Raw264.7 ATCC Cat#TIB-71 Human: HEK293 ATCC Cat# CRL-1573 Human: HEK293T ATCC Cat#ACS-4500 Human: PBMC Allcells Cat#PB003F Human: IMR-90 Cobioer Bioscience Cat#CBP60912 Experimental Models: Organisms/Strains C57BL/6J The Jackson Laboratory Cat#000664 Trex1+/ mice (Hasan et al., 2015) N/A Oligonucleotides See Table S2 for ISD This paper N/A See Table S2 for HSV 60-mer This paper N/A Poly(dA:dT) Sigma Cat#P0883 Poly(I:C) Sigma Cat#P1530 See Table S2 for qPCR primer sequences This paper N/A Recombinant DNA Gene mutants and truncations, see plasmids part in Methods details This paper N/A Software and Algorithms GraphPad Prism 7 GraphPad Software https://www.graphpad.com/ scientific-software/prism/ Origin 8 Origin Lab https://www.originlab.com

    Real-time Polymerase Chain Reaction:

    Article Title: The Cyclopeptide Astin C Specifically Inhibits the Innate Immune CDN Sensor STING.
    Article Snippet: REAGENT or RESOURCE SOURCE IDENTIFIER Critical Commercial Assays Mouse IFN-b ELISA kit PBL assay science Cat#42400-1 Fluoro HepANA Test kit MBL Cat#4220-12CN FastStart Universal SYBR Green Master(ROX) Roche Cat#34226600 Monolith NT.115 Series Capillaries Nanotemper Cat#MO-K005 Monolith Protein labeling kit RED-NHS Nanotemper Cat#MO-L001 CellTiter 96 AQueous One Solution Cell Proliferation Assay (MTS) Promega Cat#G3580 BCA Protein Assay Kit Thermo Scientific Cat#23227 Deposited Data The gene and gene product information of STING GenBank (http://www.ncbi.nlm.nih.gov/Genbank) NM_198282.3, NP_938023.1 The gene and gene product information of SCAP GenBank (http://www.ncbi.nlm.nih.gov/Genbank) NM_012235.2, NP_036367.2 The gene and gene product information of TBK1 GenBank (http://www.ncbi.nlm.nih.gov/Genbank) NM_013254.3, NP_037386.1 The gene and gene product information of IRF3 GenBank (http://www.ncbi.nlm.nih.gov/Genbank) NM_001197122.1, NP_001184051.1 The gene and gene product information of AMFR GenBank (http://www.ncbi.nlm.nih.gov/Genbank) NM_001144.5, NP_001135.3 The gene and gene product information of MAVS GenBank (http://www.ncbi.nlm.nih.gov/Genbank) NM_020746.4, NP_065797.2 The gene and gene product information of INSIG1 GenBank (http://www.ncbi.nlm.nih.gov/Genbank) NM_005542.4, NP_005533.2 The gene and gene product information of cGAS GenBank (http://www.ncbi.nlm.nih.gov/Genbank) NM_138441.2, NP_612450.2 The gene and gene product information of p65 GenBank (http://www.ncbi.nlm.nih.gov/Genbank) NM_021975.3, NP_068810.3 Protein structure of STING C-terminal domain PDB (http://www.rcsb.org/pdb/home/home.do) 4F5D Experimental Models: Cell Lines Mouse: MEFs ATCC Cat#SCRC-1008 Mouse: STING knockout MEFs (Chen et al., 2011) N/A Mouse: Raw264.7 ATCC Cat#TIB-71 Human: HEK293 ATCC Cat# CRL-1573 Human: HEK293T ATCC Cat#ACS-4500 Human: PBMC Allcells Cat#PB003F Human: IMR-90 Cobioer Bioscience Cat#CBP60912 Experimental Models: Organisms/Strains C57BL/6J The Jackson Laboratory Cat#000664 Trex1+/ mice (Hasan et al., 2015) N/A Oligonucleotides See Table S2 for ISD This paper N/A See Table S2 for HSV 60-mer This paper N/A Poly(dA:dT) Sigma Cat#P0883 Poly(I:C) Sigma Cat#P1530 See Table S2 for qPCR primer sequences This paper N/A Recombinant DNA Gene mutants and truncations, see plasmids part in Methods details This paper N/A Software and Algorithms GraphPad Prism 7 GraphPad Software https://www.graphpad.com/ scientific-software/prism/ Origin 8 Origin Lab https://www.originlab.com

    Recombinant:

    Article Title: The Cyclopeptide Astin C Specifically Inhibits the Innate Immune CDN Sensor STING.
    Article Snippet: REAGENT or RESOURCE SOURCE IDENTIFIER Critical Commercial Assays Mouse IFN-b ELISA kit PBL assay science Cat#42400-1 Fluoro HepANA Test kit MBL Cat#4220-12CN FastStart Universal SYBR Green Master(ROX) Roche Cat#34226600 Monolith NT.115 Series Capillaries Nanotemper Cat#MO-K005 Monolith Protein labeling kit RED-NHS Nanotemper Cat#MO-L001 CellTiter 96 AQueous One Solution Cell Proliferation Assay (MTS) Promega Cat#G3580 BCA Protein Assay Kit Thermo Scientific Cat#23227 Deposited Data The gene and gene product information of STING GenBank (http://www.ncbi.nlm.nih.gov/Genbank) NM_198282.3, NP_938023.1 The gene and gene product information of SCAP GenBank (http://www.ncbi.nlm.nih.gov/Genbank) NM_012235.2, NP_036367.2 The gene and gene product information of TBK1 GenBank (http://www.ncbi.nlm.nih.gov/Genbank) NM_013254.3, NP_037386.1 The gene and gene product information of IRF3 GenBank (http://www.ncbi.nlm.nih.gov/Genbank) NM_001197122.1, NP_001184051.1 The gene and gene product information of AMFR GenBank (http://www.ncbi.nlm.nih.gov/Genbank) NM_001144.5, NP_001135.3 The gene and gene product information of MAVS GenBank (http://www.ncbi.nlm.nih.gov/Genbank) NM_020746.4, NP_065797.2 The gene and gene product information of INSIG1 GenBank (http://www.ncbi.nlm.nih.gov/Genbank) NM_005542.4, NP_005533.2 The gene and gene product information of cGAS GenBank (http://www.ncbi.nlm.nih.gov/Genbank) NM_138441.2, NP_612450.2 The gene and gene product information of p65 GenBank (http://www.ncbi.nlm.nih.gov/Genbank) NM_021975.3, NP_068810.3 Protein structure of STING C-terminal domain PDB (http://www.rcsb.org/pdb/home/home.do) 4F5D Experimental Models: Cell Lines Mouse: MEFs ATCC Cat#SCRC-1008 Mouse: STING knockout MEFs (Chen et al., 2011) N/A Mouse: Raw264.7 ATCC Cat#TIB-71 Human: HEK293 ATCC Cat# CRL-1573 Human: HEK293T ATCC Cat#ACS-4500 Human: PBMC Allcells Cat#PB003F Human: IMR-90 Cobioer Bioscience Cat#CBP60912 Experimental Models: Organisms/Strains C57BL/6J The Jackson Laboratory Cat#000664 Trex1+/ mice (Hasan et al., 2015) N/A Oligonucleotides See Table S2 for ISD This paper N/A See Table S2 for HSV 60-mer This paper N/A Poly(dA:dT) Sigma Cat#P0883 Poly(I:C) Sigma Cat#P1530 See Table S2 for qPCR primer sequences This paper N/A Recombinant DNA Gene mutants and truncations, see plasmids part in Methods details This paper N/A Software and Algorithms GraphPad Prism 7 GraphPad Software https://www.graphpad.com/ scientific-software/prism/ Origin 8 Origin Lab https://www.originlab.com

    Software:

    Article Title: The Cyclopeptide Astin C Specifically Inhibits the Innate Immune CDN Sensor STING.
    Article Snippet: REAGENT or RESOURCE SOURCE IDENTIFIER Critical Commercial Assays Mouse IFN-b ELISA kit PBL assay science Cat#42400-1 Fluoro HepANA Test kit MBL Cat#4220-12CN FastStart Universal SYBR Green Master(ROX) Roche Cat#34226600 Monolith NT.115 Series Capillaries Nanotemper Cat#MO-K005 Monolith Protein labeling kit RED-NHS Nanotemper Cat#MO-L001 CellTiter 96 AQueous One Solution Cell Proliferation Assay (MTS) Promega Cat#G3580 BCA Protein Assay Kit Thermo Scientific Cat#23227 Deposited Data The gene and gene product information of STING GenBank (http://www.ncbi.nlm.nih.gov/Genbank) NM_198282.3, NP_938023.1 The gene and gene product information of SCAP GenBank (http://www.ncbi.nlm.nih.gov/Genbank) NM_012235.2, NP_036367.2 The gene and gene product information of TBK1 GenBank (http://www.ncbi.nlm.nih.gov/Genbank) NM_013254.3, NP_037386.1 The gene and gene product information of IRF3 GenBank (http://www.ncbi.nlm.nih.gov/Genbank) NM_001197122.1, NP_001184051.1 The gene and gene product information of AMFR GenBank (http://www.ncbi.nlm.nih.gov/Genbank) NM_001144.5, NP_001135.3 The gene and gene product information of MAVS GenBank (http://www.ncbi.nlm.nih.gov/Genbank) NM_020746.4, NP_065797.2 The gene and gene product information of INSIG1 GenBank (http://www.ncbi.nlm.nih.gov/Genbank) NM_005542.4, NP_005533.2 The gene and gene product information of cGAS GenBank (http://www.ncbi.nlm.nih.gov/Genbank) NM_138441.2, NP_612450.2 The gene and gene product information of p65 GenBank (http://www.ncbi.nlm.nih.gov/Genbank) NM_021975.3, NP_068810.3 Protein structure of STING C-terminal domain PDB (http://www.rcsb.org/pdb/home/home.do) 4F5D Experimental Models: Cell Lines Mouse: MEFs ATCC Cat#SCRC-1008 Mouse: STING knockout MEFs (Chen et al., 2011) N/A Mouse: Raw264.7 ATCC Cat#TIB-71 Human: HEK293 ATCC Cat# CRL-1573 Human: HEK293T ATCC Cat#ACS-4500 Human: PBMC Allcells Cat#PB003F Human: IMR-90 Cobioer Bioscience Cat#CBP60912 Experimental Models: Organisms/Strains C57BL/6J The Jackson Laboratory Cat#000664 Trex1+/ mice (Hasan et al., 2015) N/A Oligonucleotides See Table S2 for ISD This paper N/A See Table S2 for HSV 60-mer This paper N/A Poly(dA:dT) Sigma Cat#P0883 Poly(I:C) Sigma Cat#P1530 See Table S2 for qPCR primer sequences This paper N/A Recombinant DNA Gene mutants and truncations, see plasmids part in Methods details This paper N/A Software and Algorithms GraphPad Prism 7 GraphPad Software https://www.graphpad.com/ scientific-software/prism/ Origin 8 Origin Lab https://www.originlab.com



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